![]() ![]() "We think that's because First Nations peoples' genetic background is Rhesus D positive, and is where we find a large number of Indigenous communities. The highest proportion of positive blood was found in the Northern Territory, followed by Victoria and New South Wales, Dr Hirani said. There were differences between states and territories too. When we see blood types written as, say, "O positive" or "AB negative", this provides information about two different blood group systems. Like eye colour, your blood type is inherited, and it refers to the presence or absence of certain molecules, called antigens, scattered over the surface of your red blood cells. "If Australia continues … becoming more positive, then I think we could possibly look at how positive blood could become the universal type that we use in some emergencies." What's behind this blood type shift? "Now we can start to make some plans for the future outreach programs to various different communities to diversify the cultural representation of our blood donors," Dr Hirani said. Rena Hirani, who led the study, says information about the nation's shifting blood types not only gives blood donation organisations a better idea of what they can collect from the community, but it may also affect how emergency blood transfusions are done down the track. The blood type audit results were published in the Medical Journal of Australia. However, the neutralizing effect could be a characteristic of anti‐A isoagglutinins belonging to IgG class (predominant in O blood type individuals) and not of those belonging to IgM class (predominant in B blood group subjects).A trio of researchers from Australian Red Cross Lifeblood analysed blood types from more than a million people from across the country, and found rates of a couple of traditionally rarer blood types also jumped up a few percentage points. ![]() ![]() This finding could be in contrast with the hypothesized anti‐SARS‐CoV‐2 activity of anti‐A isoagglutinins, which are present also in B group individuals. Interestingly, considering O and B blood groups together and comparing them with the other blood types, the O blood type‐related protective effect disappeared (Table (Table1). When considering in CP donors the clinical course of the disease, O blood type did not appear as a modulator of the severity of COVID‐19 (Table (Table1 1 bottom section). According to these data, the relative risk (and 95% confidence interval) of having experienced SARS‐CoV‐2 infection in O blood type subjects is estimated as 0♷4 (0♶–0♹0), thus suggesting the protective role of O blood type towards SARS‐CoV‐2 contraction. The prevalence of O blood type in CP donors was significantly lower than that observed in healthy blood donors of Mantua and Pavia (Table (Table1). Indeed, in accordance with the Italian transfusion law for the prevention of transfusion‐related acute lung injury (TRALI), only nulliparous women can donate CP. The two analytical population were comparable in terms of age, whereas as expected an extra representation of males was observed in CP donors. These subjects were compared with an historical series of 16 911 healthy blood donors from the same geographical area (Table (Table1, 1, upper section). All CP donors were of Caucasian origin and were recovered (clinical resolution of symptoms from at least 14 days with two consecutive negative SARS‐CoV‐2 RT‐PCR nasal swabs) from coronavirus disease 2019 (COVID‐19). During the period between 25 March 2020 and 22 June 2020, 447 consecutive CP donors were enrolled at the University Hospital of Pavia and the City Hospital of Mantova, Lombardy region, Italy. To verify the protective effect of O blood type against SARS‐CoV‐2 infection, we have compared the ABO blood group distribution of all donors of convalescent plasma (CP) with that of healthy uninfected periodic volunteer blood donors. The reason for this phenomenon could reside in the presence in O blood group subjects of IgG anti‐A isoagglutinins which would prevent the binding of SARS‐CoV‐2 to its receptor thereby inhibiting the virus entry into the targeted human cells. In particular, it has been hypothesized that individuals belonging to O blood type are less susceptible to SARS‐CoV‐2 infection than those belonging to non‐O blood groups. ![]() Recent evidence has suggested a relationship between the ABO blood group and the susceptibility of developing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). ABO antigens, which are ubiquitously expressed on the surface of human cells and tissues, have been implied in a wide array of diseases, first of all cardiovascular disorders. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |